7-溴-4-氯噻吩并[3,2-d]嘧啶合成路线 （共 11 条）
反应条件
trichlorophosphate 2 h; Heating / reflux;
参考文献
Thrash, Thomas; Cabell, Larry A.; Lohse, Daniel; Budde, Raymond J.A.
Patent: US2006/4002 A1, 2006 ;
Location in patent: Page/Page column 39 ;
反应条件
sodium hydrogencarbonate in trichlorophosphate
参考文献
Board of Regents, The University of Texas System
Patent: US6503914 B1, 2003 ;
反应条件
bromine; sodium hydrogencarbonate in acetic acid
参考文献
Board of Regents, The University of Texas System
Patent: US6503914 B1, 2003 ;
反应条件
N-bromosuccinmide; acetic acid in acetonitrile T=85°C; 18 h;
参考文献
WO2011/159657 A1, ;
Page/Page column 54 ;
反应条件
sulfuryl dichloride in dichloromethane; acetonitrile T=0°C; 0.5 h;
参考文献
Ham, Young Jin; Lee, Duck-Hyung; Choi, Hwan Geun; Hah, Jung-Mi; Sim, Taebo
Tetrahedron Letters, 2010 , vol. 51, # 35 p. 4609 - 4611
反应条件
1: Br2 2: POCl3 View Scheme
参考文献
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, , vol. 267, p. 697 - 700
反应条件
1.1: acetic anhydride 1.2: 3 h / 20 °C 1.3: 20 h / 20 - 150 °C 2.1: bromine / acetic acid / 18 h / 120 °C 3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / |Reflux View Scheme
反应条件
hydrogen; palladium on activated charcoal
参考文献
Robba,M. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 3630 - 3636
反应条件
ammonia in isopropyl alcohol T=95 - 100°C; 7 h; Sealed tube;
参考文献
HANMI PHARM. CO., LTD.; BANG, Keuk Chan; PARK, Chang Hee; CHOI, Jae Yul; KIM, Seo Hee; HAM, Young Jin
Patent: WO2014/3483 A1, 2014 ;
Location in patent: Page/Page column 20 ;
反应条件
hydrogen; palladium on activated charcoal
参考文献
Robba,M. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 3630 - 3636
