(5-三氟甲基吡啶-2-基)甲醇合成路线 （共 7 条）
反应条件
methanol; sodium tetrahydroborate T=0 - 20°C;
参考文献
GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, IV, Siegfried Benjamin; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing; LIN, Xiaojuan; XU, Shanli; LV, Maoyun; YAO, Chen; LI, Lei; HUANG, Xing; GAO, Min
Patent: WO2013/166621 A1, 2013 ;
Location in patent: Page/Page column 48 ;
反应条件
sodium tetrahydroborate in methanol T=-78 - 20°C; 0.5 h;
参考文献
Thompson, Andrew M.; Sutherland, Hamish S.; Palmer, Brian D.; Kmentova, Iveta; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6563 - 6585
反应条件
1.1: n-butyllithium / hexane; toluene / 0.58 h / -78 °C 1.2: 1 h / -78 °C 2.1: sodium tetrahydroborate / methanol / 0.5 h / -78 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6563 - 6585
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 80 °C / 11251.1 Torr 2: sodium tetrahydroborate; methanol / 0 - 20 °C View Scheme
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 0.333333 h;
参考文献
ABBOTT LABORATORIES
Patent: US2009/124666 A1, 2009 ;
Location in patent: Page/Page column 26 ;
反应条件
2,4,6-trichloro-1,3,5-triazine in dichloromethane; N,N-dimethyl-formamide T=20°C; 60 h; Reflux;
参考文献
Thompson, Andrew M.; Sutherland, Hamish S.; Palmer, Brian D.; Kmentova, Iveta; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6563 - 6585
反应条件
phosphorus tribromide in dichloromethane T=0 - 20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2009/103478 A1, 2009 ;
Location in patent: Page/Page column 51 ;
WO 2009/103478 A1
