乙基2-环己基-2-羟基苯乙酸酯合成路线 （共 10 条）
反应条件
in tetrahydrofuran; diethyl ether T=0 - 20°C; 3.75 h;
参考文献
NEKTAR THERAPEUTICS AL, CORPORATION
Patent: WO2008/112261 A1, 2008 ;
Location in patent: Page/Page column 37 ;
反应条件
lithium diisopropyl amide in tetrahydrofuran 1.) -78 deg C, 15 min; 2.) warm up to RT, 1 h;
参考文献
Aitken, R. Alan; Thomas, Andrew W.
Synlett, 1997 , vol. 1997, # 3 p. 293 - 294
反应条件
magnesium 1.) ether, reflux, 1 h, 2.) ether, reflux, 18 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 9 p. 1103 - 1106
反应条件
sodium hydroxide; water in methanol T=80°C; 3.5 h;
参考文献
NEKTAR THERAPEUTICS AL, CORPORATION
Patent: WO2008/112261 A1, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
sodium hydroxide; water in methanol T=80°C; 3.5 h;
参考文献
NEKTAR THERAPEUTICS AL, CORPORATION
Patent: WO2008/112261 A1, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
T=650°C; P=0.01 Torr;
参考文献
Aitken, R. Alan; Thomas, Andrew W.
Synlett, 1997 , vol. 1997, # 3 p. 293 - 294
反应条件
sodium 1.) benzene, reflux, 0.5 h, 2.) benzene, reflux, 18 h; Yield given. Multistep reaction;
参考文献
Rzeszotarski, W. J.; Gibson, R. E.; Eckelman, W. C.; Simms, D. A.; Jagoda, E. M.; et al.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1103 - 1106
反应条件
sodium hydroxide; water in methanol T=80°C; 3.5 h;
参考文献
NEKTAR THERAPEUTICS AL, CORPORATION
Patent: WO2008/112261 A1, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
sodium hydroxide; water in methanol T=80°C; 3.5 h;
参考文献
NEKTAR THERAPEUTICS AL, CORPORATION
Patent: WO2008/112261 A1, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
1: aqueous methanol. potassium carbonate 2: potassium carbonate; ethyl acetate View Scheme
参考文献
Adlerova,E. et al.
Collection of Czechoslovak Chemical Communications, 1964 , vol. 29, p. 97 - 120
