4,4-二甲基-1-戊醇合成路线 （共 37 条）
反应条件
1: 68 percent / KI / dimethylsulfoxide / 12 h / 95 °C 2: 63 percent / aq. KOH / ethanol / 12 h / Heating 3: 76 percent / LiAlH4 / diethyl ether / 12 h / Heating View Scheme
参考文献
Sasse, Astrid; Ligneau, Xavier; Rouleau, Agnes; Elz, Sigurd; Ganellin, C. Robin; Arrang, Jean-Michel; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Journal of Medicinal Chemistry, 2002 , vol. 45, # 18 p. 4000 - 4010
反应条件
1: 63 percent / aq. KOH / ethanol / 12 h / Heating 2: 76 percent / LiAlH4 / diethyl ether / 12 h / Heating View Scheme
参考文献
Sasse, Astrid; Ligneau, Xavier; Rouleau, Agnes; Elz, Sigurd; Ganellin, C. Robin; Arrang, Jean-Michel; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Journal of Medicinal Chemistry, 2002 , vol. 45, # 18 p. 4000 - 4010
反应条件
1: diethyl ether 2: platinum oxide / Hydrogenation View Scheme
参考文献
Bartlett; Rosen
Journal of the American Chemical Society, 1942 , vol. 64, p. 544
反应条件
hydrogen; methanesulfonic acid; lt;Pt(C2H4)(DPPB)gt; in toluene T=100°C; P=38000 Torr; var. olefins; Product distribution;
参考文献
Botteghi, Carlo; Paganelli, Stefano
Journal of Organometallic Chemistry, 1991 , vol. 417, # 1/2 p. C41 - C45
反应条件
1.1: n-butyllithium / diethyl ether; hexane / 1.25 h / -78 - -40 °C 1.2: 3 h / -78 - 23 °C 2.1: palladium 10 on activated carbon; hydrogen / ethanol / 16 h View Scheme
参考文献
BAHRENBERG, Gregor; KUEHNERT, Sven; LUCAS, Simon; SCHROEDER, Wolfgang
Patent: US2013/281452 A1, 2013 ;
参考文献
Whitmore et al.
Journal of the American Chemical Society, 1941 , vol. 63, p. 647
反应条件
1.1: Mg / diethyl ether / 2 h / 20 °C 1.2: 43.9 percent / diethyl ether / 1 h / 20 °C 2.1: 44.8 percent / LiAlH4 / diethyl ether / 5 h / Heating View Scheme
参考文献
Hamano, Hiroshi; Nagata, Keiichi; Fukada, Nobuo; Shimotahira, Hiroshi; Ju, Xiu-Lian; Ozoe, Yoshihisa
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 665 - 674
反应条件
1.1: 99.2 percent / PBr3; pyridine / 12 h / Heating 2.1: Mg / diethyl ether / 2 h / 20 °C 2.2: 43.9 percent / diethyl ether / 1 h / 20 °C 3.1: 44.8 percent / LiAlH4 / diethyl ether / 5 h / Heating View Scheme
参考文献
Hamano, Hiroshi; Nagata, Keiichi; Fukada, Nobuo; Shimotahira, Hiroshi; Ju, Xiu-Lian; Ozoe, Yoshihisa
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 665 - 674
反应条件
(i) B2H6, THF, (ii) aq. NaOH, aq. H2O2; Multistep reaction;
参考文献
Wagner,P.J. et al.
Journal of the American Chemical Society, 1972 , vol. 94, p. 7500 - 7506
反应条件
diethyl ether T=-12 - -10°C; zuletz bei Siedetemperatur;
参考文献
Malinowski; Wolkowa; Morosowa
Zhurnal Obshchei Khimii, vol. 19, p. 116
Chem.Abstr., 1949 , p. 6155
