6-(甲氧基甲基)-4(1H)-嘧啶酮合成路线 （共 5 条）
反应条件
1: With methanol; sodium methylate 18 h; Reflux; 2: With hydrogenchloride in water pH=7;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.
Patent: WO2011/53292 A1, 2011 ;
Location in patent: Page/Page column 220 ;
WO 2011/053292 A1
反应条件
1: With sodium methylate in methanol T=20°C; 1 h; 2: With acetic acid
参考文献
Das, Jagabandhu; Padmanabha, Ramesh; Chen, Ping; Norris, Derek J.; Doweyko, Arthur M.P.; Barrish, Joel C.; Wityak, John; Lombardo, Louis J.; Lee, Francis Y.F.
Patent: US2004/54186 A1, 2004 ;
Location in patent: Page 127-128 ;
US 20040054186 A1
参考文献
Smith Kline and French Laboratories Limited
Patent: US4777172 A1, 1988 ;
反应条件
1.1: trichlorophosphate / dichloromethane / 18 h / 20 °C 1.2: pH 7 2.1: ammonium hydroxide / 3 h / Sealed tube View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.
Patent: WO2011/53292 A1, 2011 ;
WO 2011/053292 A1
反应条件
1: With trichlorophosphate in dichloromethane T=20°C; 18 h; 2: With water; sodium hydroxide in water pH=7;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.
Patent: WO2011/53292 A1, 2011 ;
Location in patent: Page/Page column 221 ;
WO 2011/053292 A1
