4-氯-6-(甲氧基甲基)嘧啶合成路线 （共 3 条）
反应条件
1: With trichlorophosphate in dichloromethane T=20°C; 18 h; 2: With water; sodium hydroxide in water pH=7;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.
Patent: WO2011/53292 A1, 2011 ;
Location in patent: Page/Page column 221 ;
WO 2011/053292 A1
反应条件
ammonium hydroxide 3 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.
Patent: WO2011/53292 A1, 2011 ;
Location in patent: Page/Page column 221 ;
WO 2011/053292 A1
反应条件
potassium phosphate in 1-methyl-pyrrolidin-2-one T=90°C; 4 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/104538 A1, 2007 ;
Location in patent: Page/Page column 64 ;
WO 2007/104538 A1
