5-(三氟甲基)吡啶-2-甲醛合成路线 （共 4 条）
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 0.333333 h;
参考文献
ABBOTT LABORATORIES
Patent: US2009/124666 A1, 2009 ;
Location in patent: Page/Page column 26 ;
反应条件
1: 2-iodo-5-(trifluoromethyl)pyridine With n-butyllithium in hexane; toluene T=-78°C; 0.583333 h; 2: N,N-dimethyl-formamide in hexane; toluene T=-78°C; 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6563 - 6585
反应条件
sodium tetrahydroborate in methanol T=-78 - 20°C; 0.5 h;
参考文献
Thompson, Andrew M.; Sutherland, Hamish S.; Palmer, Brian D.; Kmentova, Iveta; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6563 - 6585
反应条件
1: sodium tetrahydroborate / methanol / 0.5 h / -78 - 20 °C 2: 2,4,6-trichloro-1,3,5-triazine / dichloromethane; N,N-dimethyl-formamide / 60 h / 20 °C / Reflux View Scheme
参考文献
Thompson, Andrew M.; Sutherland, Hamish S.; Palmer, Brian D.; Kmentova, Iveta; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6563 - 6585
