2-[2-(2-氟苯基)-2-氧代乙基]丙二腈合成路线 （共 2 条）
反应条件
water; hydrogen; acetic acid in tetrahydrofuran
T=45 - 50°C; 5 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2011/306769 A1, 2011 ;
Location in patent: Page/Page column 39 ;
反应条件
1.1: hydrogenchloride / tetrahydrofuran / 3 h / 55 - 65 °C
2.1: hydrogen; N-ethyl-N,N-diisopropylamine / 5 palladium on charcoal / ethanol / 7 h / 15 - 25 °C / Autoclave
3.1: hydrogen; acetic acid / Raney-nickel / water; tetrahydrofuran / 3 h / 15 - 25 °C
3.2: 10 - 35 °C / pH 7 - 8
3.3: 15 - 25 °C / pH 3 - 3.5
View Scheme
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2011/306769 A1, 2011 ;
