1: 91 percent / methanol / 7 h 2: 92 percent / LiOH; H2O / dioxane / 20 h View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 99 percent / DMAP; Et₃N / CH₂Cl₂ <br />2: 96 percent / NH₃ / methanol / 0 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: aq. CF₃COOAg; TEA / tetrahydrofuran / 4 h / 20 &deg;C<br />2: TEA / CH₂Cl₂ / 0.5 h / 0 &deg;C<br />3: 0.25 g / NH₃ / CH₂Cl₂ / 0.5 h / 0 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: tetrahydrofuran / 1 h / -5 &deg;C<br />2: aq. CF₃COOAg; TEA / tetrahydrofuran / 4 h / 20 &deg;C<br />3: TEA / CH₂Cl₂ / 0.5 h / 0 &deg;C<br />4: 0.25 g / NH₃ / CH₂Cl₂ / 0.5 h / 0 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: TEA / tetrahydrofuran / 0.25 h / -15 &deg;C<br />2: tetrahydrofuran / 1 h / -5 &deg;C<br />3: aq. CF₃COOAg; TEA / tetrahydrofuran / 4 h / 20 &deg;C<br />4: TEA / CH₂Cl₂ / 0.5 h / 0 &deg;C<br />5: 0.25 g / NH₃ / CH₂Cl₂ / 0.5 h / 0 &deg;C<br /> <br /> &nbsp;