alpha-(苯基甲基)[1,1'-联苯]-4-甲醇合成路线 (共 7 条)
反应条件
in tetrahydrofuran T=20°C; Grignard reaction;
参考文献
Hu, Qingzhong; Negri, Matthias; Jahn-Hoffmann, Kerstin; Zhuang, Yan; Olgen, Sureyya; Bartels, Marc; Mueller-Vieira, Ursula; Lauterbach, Thomas; Hartmann, Rolf W.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 16 p. 7715 - 7727
反应条件
sodium tetrahydroborate
参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195
反应条件
1: PBr3
2: (i) NaH, DMF, (ii) /BRN= 2117276/, (iii) aq. NaOH, EtOH
3: polyphosphoric acid / 160 - 170 °C
4: NaBH4
5: 160 - 170 °C
View Scheme
参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195
反应条件
1: PBr3
2: (i) NaH, DMF, (ii) /BRN= 2117276/, (iii) aq. NaOH, EtOH
3: polyphosphoric acid / 160 - 170 °C
4: NaBH4
5: PBr3
View Scheme
参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195
反应条件
1: PBr3
2: (i) NaH, DMF, (ii) /BRN= 2117276/, (iii) aq. NaOH, EtOH
View Scheme
参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195
反应条件
1: PBr3
2: (i) NaH, DMF, (ii) /BRN= 2117276/, (iii) aq. NaOH, EtOH
3: polyphosphoric acid / 160 - 170 °C
View Scheme
参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195
反应条件
phosphorus tribromide
参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195