1-苄基-2,4,5-三溴-1H-咪唑合成路线 （共 12 条）
反应条件
caesium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/14900 A1, 2004 ;
Location in patent: Page 39 ;
WO 2004/014900 A1
反应条件
sodium carbonate in N,N-dimethyl-formamide Heating;
参考文献
Iddon, Brian; Khan, Nazir; Lim, Bee Lan
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1437 - 1444
反应条件
sodium hydride in tetrahydrofuran Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 33, # 40 p. 5865 - 5868
反应条件
n-butyllithium; water in diethyl ether; hexane T=-78°C; 1 h;
参考文献
Krall, Jacob; Jensen, Claus H.; Sorensen, Troels E.; Nielsen, Birgitte; Jensen, Anders A.; Sander, Tommy; Balle, Thomas; Frolund, Bente
Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6536 - 6540
反应条件
sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium(0); N,N,N',N,-tetramethylethylenediamine; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in tetrahydrofuran T=0°C; 3 h; Inert atmosphere; Reagent/catalystTime; regioselective reaction;
参考文献
Chelucci, Giorgio; Baldino, Salvatore; Ruiu, Andrea
Journal of Organic Chemistry, 2012 , vol. 77, # 21 p. 9921 - 9925,5
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 25°C; 1 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1453 - 1456
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 25°C; 1 h;
参考文献
Iddon, Brian; Khan, Nazir
Tetrahedron Letters, 1986 , vol. 27, # 14 p. 1635 - 1638
反应条件
Yield given. Multistep reaction;
参考文献
Iddon, Brian; Khan, Nazir
Tetrahedron Letters, 1986 , vol. 27, # 14 p. 1635 - 1638
反应条件
sodium isopropanolate in isopropyl alcohol 5 h; Heating;
参考文献
Iddon, Brian; Khan, Nazir; Lim, Bee Lan
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1437 - 1444
反应条件
in isopropyl alcohol Heating;
参考文献
Iddon, Brian; Khan, Nazir; Lim, Bee Lam
Journal of the Chemical Society, Chemical Communications, 1985 , # 20 p. 1428 - 1429
