8-氯-5,6-二氢-11H-苯并[5,6]环庚烷并[1,2-b]吡啶-11-酮合成路线 （共 19 条）
反应条件
1: With trifluorormethanesulfonic acid T=60°C; 1 h; 2: With hydrogenchloride in water T=20°C; 1 h; Heating / reflux;
参考文献
ALANTOS PHARMACEUTICALS, INC.
Patent: WO2006/116157 A2, 2006 ;
Location in patent: Page/Page column 56-57 ;
WO 2006/116157 A2
反应条件
n-butyllithium in tetrahydrofuran; cyclohexane T=-78°C; 0.166667 h;
参考文献
Poirier, Marc; Chen, Frank; Bernard, Charles; Wong, Yee-Shing; Wu, George G.
Organic Letters, 2001 , vol. 3, # 23 p. 3795 - 3798
反应条件
1: With thionyl chloride T=30 - 60°C; 2: With AlCl3, aluminium chloride in 1,2-dichloro-ethane T=-5 - 20°C;
参考文献
EP1098882 B1, ;
Page 8 ;
反应条件
trichlorophosphate in hexane; water; chlorobenzene
参考文献
Schering Corporation
Patent: US6372909 B1, 2002 ;
反应条件
aluminium trichloride in hexane; dichloromethane; toluene
参考文献
Schering Corporation
Patent: US6372909 B1, 2002 ;
反应条件
1.1: 121 g / (MeO)3B; BH3*Me2S / tetrahydrofuran / 18 h / 20 °C 2.1: PPh3; Br2 / acetonitrile / 1 h / 20 °C 3.1: LDA; t-BuOMe / various solvent(s); tetrahydrofuran / -30 - 0 °C 4.1: NaH / dimethylformamide / 1 h / 0 °C 4.2: 10 g / dimethylformamide / 0.25 h / 0 °C 5.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C View Scheme
参考文献
Organic Letters, , vol. 3, # 23 p. 3795 - 3798
反应条件
1.1: PPh3; Br2 / acetonitrile / 1 h / 20 °C 2.1: LDA; t-BuOMe / various solvent(s); tetrahydrofuran / -30 - 0 °C 3.1: NaH / dimethylformamide / 1 h / 0 °C 3.2: 10 g / dimethylformamide / 0.25 h / 0 °C 4.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C View Scheme
参考文献
Organic Letters, , vol. 3, # 23 p. 3795 - 3798
反应条件
1.1: LDA; t-BuOMe / various solvent(s); tetrahydrofuran / -30 - 0 °C 2.1: NaH / dimethylformamide / 1 h / 0 °C 2.2: 10 g / dimethylformamide / 0.25 h / 0 °C 3.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C View Scheme
参考文献
Organic Letters, , vol. 3, # 23 p. 3795 - 3798
反应条件
1.1: NaH / dimethylformamide / 1 h / 0 °C 1.2: 10 g / dimethylformamide / 0.25 h / 0 °C 2.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C View Scheme
参考文献
Organic Letters, , vol. 3, # 23 p. 3795 - 3798
反应条件
1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating 3: PPA / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 457 - 461
