1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Inert atmosphere; 2: With water; ammonium chloride in tetrahydrofuran; hexane Inert atmosphere;

<b>Multi-step reaction with 2 steps<br /> </b>1: 100 percent / triethylamine; copper(I) iodide / PdCl₂(PPh₃)2 / 3 h / 20 &deg;C<br />2: 100 percent / I₂ / CH₂Cl₂ / 0.17 h / 25 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: copper(l) iodide; Pd₂(PPh₃)₂Cl₂; diethylamine / 20 &deg;C / Inert atmosphere<br />2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; lithium hexamethyldisilazane / toluene / 0.03 h / Inert atmosphere<br />2.2: 120 &deg;C / Inert atmosphere<br />3.1: iodine; cesium fluoride / tetrahydrofuran / 20 &deg;C / Inert atmosphere; Molecular sieve<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: copper(l) iodide; Pd₂(PPh₃)₂Cl₂; diethylamine / 20 &deg;C / Inert atmosphere<br />2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; lithium hexamethyldisilazane / toluene / 0.03 h / Inert atmosphere<br />2.2: 120 &deg;C / Inert atmosphere<br />3.1: iodine; cesium fluoride / tetrahydrofuran / 20 &deg;C / Inert atmosphere; Molecular sieve<br /> <br /> &nbsp;