4-氯呋喃并[3,2-c]吡啶合成路线 （共 20 条）
反应条件
1: With acetic acid; zinc 2 h; Reflux; 2: With sodium hydroxide in water
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2100895 A1, 2009 ;
Location in patent: Page/Page column 45 ;
反应条件
in ethanol T=120°C; 24 h;
参考文献
New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156
反应条件
1: With N-(diphenylmethylene)amine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene T=80°C; 3 h; Inert atmosphere; 2: With hydroxylamine in methanol T=20°C; 18 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.
Patent: WO2011/53292 A1, 2011 ;
Location in patent: Page/Page column 135 ;
WO 2011/053292 A1
参考文献
Akzo Nobel N.V.
Patent: US6194409 B1, 2001 ;
反应条件
sodium hydroxide; bromine in methanol; tetrachloromethane
反应条件
1: Br2 / CCl4 / 20 °C 2: DBU / tetrahydrofuran; CCl4 / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 1 p. 250 - 254
反应条件
tert.-butyl lithium
1.) THF, -70 deg C to -65 deg C, 10 min, 2.) -65 deg C, 15 min; -65 deg C to room temperature, 45 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bisagni, E.; Hung, N. Chi; Lhoste, J. M.
Tetrahedron, 1983 , vol. 39, # 10 p. 1777 - 1782
反应条件
tert.-butyl lithium
1.) THF, -70 deg C to -65 deg C, 10 min, 2.) -65 deg C, 15 min; -65 deg C to room temperature, 45 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bisagni, E.; Hung, N. Chi; Lhoste, J. M.
Tetrahedron, 1983 , vol. 39, # 10 p. 1777 - 1782
反应条件
1: Br2 / CCl4 / 20 °C
2: DBU / tetrahydrofuran; CCl4 / 20 °C
3: 47 percent / aq. NH3 / dioxane / 150 °C
View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
参考文献
Akzo Nobel N.V.
Patent: US6194409 B1, 2001 ;
