2-溴-3-甲基萘-1,4-二酮合成路线 （共 18 条）
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide in 1,4-dioxane
T=80°C; Stille coupling; 7 h; Inert atmosphere;
参考文献
Azuma, Shuhei; Nishio, Kazuyuki; Kubo, Konomi; Sasamori, Takahiro; Tokitoh, Norihiro; Kuramochi, Kouji; Tsubaki, Kazunori
Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4812 - 4820
反应条件
potassium hydroxide in methanol
1 h; Reflux;
参考文献
Nasiri, Hamid Reza; Madej, M. Gregor; Panisch, Robin; Lafontaine, Michael; Bats, Jan W.; Lancaster, C. Roy D.; Schwalbe, Harald
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9530 - 9541
反应条件
1: 3-bromo-2-methyl-1,4-naphthoquinone With potassium hydroxide; sodium dithionite; tetra-(n-butyl)ammonium iodide in tetrahydrofuran; water
T=20°C;
2: dimethyl sulfate in tetrahydrofuran; water
T=20°C; 18 h;
参考文献
Payne, Richard J.; Daines, Alison M.; Clark, Bruce M.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 22 p. 5785 - 5791
反应条件
1: 98 percent / SnCl2*2H2O; aq. HCl / ethanol
2: 88 percent / aq. KOH / 1 h / Heating
View Scheme
参考文献
Adams et al.
Journal of the American Chemical Society, 1941 , vol. 63, p. 528,532
反应条件
1.1: 98 percent / SnCl2*2H2O; aq. HCl / ethanol
2.1: 88 percent / aq. KOH / 1 h / Heating
3.1: n-BuLi / tetrahydrofuran / -78 °C
3.2: B(OMe)3 / tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Pathak, Rakhi; Vandayar, Kantharuby; Van Otterlo, Willem A. L.; Michael, Joseph P.; Fernandes, Manuel A.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3504 - 3509
反应条件
Behandeln des Reaktionsprodukts mit Ag2O und MgSO4 in Aether;
参考文献
Andrews et al.
Journal of the Chemical Society, 1956 , p. 1844,1850
反应条件
hydrogenchloride; tin(ll) chloride in ethanol
参考文献
Pathak, Rakhi; Vandayar, Kantharuby; Van Otterlo, Willem A. L.; Michael, Joseph P.; Fernandes, Manuel A.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3504 - 3509
反应条件
triethylamine in acetonitrile
10 h;
参考文献
Aldersley, Michael F.; Chishti, Shuhid H.; Dean, Francis M.; Douglas, Mark E.; Ennis, David S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 8 p. 2163 - 2174
