N-(1-苄基哌啶-4-基)异丁酰胺合成路线 (共 3 条)
反应条件
triethylamine in dichloromethane T=20 - 40°C; 1 h;
参考文献
AstraZeneca AB
Patent: US2008/139613 A1, 2008 ;
Location in patent: Page/Page column 10 ;
US 20080139613 A1
反应条件
sodium hydroxide in diethyl ether T=20°C;
参考文献
Barber, Christopher G.; Blakemore, David C.; Chiva, Jean-Yves; Eastwood, Rachel L.; Middleton, Donald S.; Paradowski, Kerry A.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1499 - 1503
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran T=20°C; 10 h;
参考文献
Fan, Xing; Zhang, Hu-Shan; Chen, Li; Long, Ya-Qiu
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2827 - 2840