4-(1,3-二氧代异吲哚啉-2-基)丁酸合成路线 （共 31 条）
参考文献
Guenin, Erwann; Monteil, Maelle; Bouchemal, Nadia; Prange, Thierry; Lecouvey, Marc
European Journal of Organic Chemistry, 2007 , # 20 p. 3380 - 3391
反应条件
in water; N,N-dimethyl-formamide
参考文献
ISTITUTO CHIMICO INTERNAZIONALE, DR. GIUSEPPE RENDE S.R.L.
Patent: EP354881 A1, 1990 ;
反应条件
sodium carbonate in water 5 h; Ambient temperature;
参考文献
Kolasa, Teodozyj; Miller, Marvin J.
Journal of Organic Chemistry, 1990 , vol. 55, # 14 p. 4246 - 4255
参考文献
Hoechst Aktiengesellschaft
Patent: US5061807 A1, 1991 ;
反应条件
in toluene 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
BIOVITRUM AB
Patent: WO2005/75471 A2, 2005 ;
Location in patent: Page/Page column 127 ;
WO 2005/075471 A2
反应条件
in acetonitrile Decarboxylation; 30 h; Irradiation;
参考文献
Yoon, Ung Chan; Lee, Chan Woo; Oh, Sun Wha; Mariano, Patrick S.
Tetrahedron, 1999 , vol. 55, # 41 p. 11997 - 12008
反应条件
propionic acid 4 h; Heating;
参考文献
Zav'yalov; Dorofeeva; Rumyantseva; Kulikova; Ezhova; Kravchenko; Zavozin
Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 8 p. 440 - 442
参考文献
Apelt; Grassmann; Ligneau; Pertz; Ganellin; Arrang; Schwartz; Schunack; Stark, Holger
Pharmazie, 2005 , vol. 60, # 2 p. 97 - 106
反应条件
1: 225 mg / sodium bicarbonate / H2O / 1 h / Ambient temperature 2: 13 mg / potassium permanganate, sulfuric acid (1 N) / 1 h / Ambient temperature View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 60, p. 2810 - 2820
反应条件
1: pyridine / 100 °C 2: platinum; ethanol / Hydrogenation View Scheme
参考文献
Journal of Organic Chemistry, , vol. 19, p. 1589,1591
