4-甲基二苯并[b,d]噻吩合成路线 （共 16 条）
反应条件
1: With sulfuric acid T=0 - 25°C; 2: With potassium carbonate in water pH=8;
参考文献
Pandya, Vrajesh B.; Jain, Mukul R.; Chaugule, Balaji V.; Patel, Jigar S.; Parmar, Bhavesh M.; Joshi, Jignesh K.; Patel, Pankaj R.
Synthetic Communications, 2012 , vol. 42, # 4 p. 497 - 505
反应条件
lithium aluminium tetrahydride in diethyl ether 1.5 h; Heating;
参考文献
Boberg, Friedrich; Bruns, Wolfgang; Musshoff, Dagmar
Phosphorus, Sulfur and Silicon and the Related Elements, 1992 , vol. 72, # 1-4 p. 13 - 32
反应条件
T=650°C; P=0.001 Torr;
参考文献
Black, Michael; Cadogan, J. I. G.; McNab, Hamish
Journal of the Chemical Society, Chemical Communications, 1990 , # 5 p. 395 - 396
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Samanta, Rajarshi; Antonchick, Andrey P.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 22 p. 5217 - 5220
反应条件
1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Inert atmosphere 2: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Samanta, Rajarshi; Antonchick, Andrey P.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 22 p. 5217 - 5220
反应条件
1: 4-fluoro-1-iodobenzene; silver(I) acetate; palladium dichloride / acetic acid / 44 h / 110 °C 2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Inert atmosphere 3: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Samanta, Rajarshi; Antonchick, Andrey P.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 22 p. 5217 - 5220
反应条件
1: silver(I) acetate; palladium dichloride / acetic acid / 16 h / 110 °C 2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Inert atmosphere 3: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Samanta, Rajarshi; Antonchick, Andrey P.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 22 p. 5217 - 5220
反应条件
1.1: dihydrogen peroxide; vanadium pentoxide / water; acetonitrile / 0 - 10 °C / Inert atmosphere 2.1: sulfuric acid / 0 - 25 °C 2.2: pH 8 View Scheme
参考文献
Pandya, Vrajesh B.; Jain, Mukul R.; Chaugule, Balaji V.; Patel, Jigar S.; Parmar, Bhavesh M.; Joshi, Jignesh K.; Patel, Pankaj R.
Synthetic Communications, 2012 , vol. 42, # 4 p. 497 - 505
反应条件
n-butyllithium; diethyl ether
参考文献
Gilman; Wilder
Journal of Organic Chemistry, 1957 , vol. 22, p. 523,524
反应条件
T=650°C; Flash vacuum pyrolysis;
参考文献
Black, Michael; Cadogan; McNab, Hamish
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 13 p. 2961 - 2967
