2-三氟甲基-1H-苯并咪唑-7-羧酸甲酯合成路线 （共 4 条）
反应条件
hydrogen; 10percent Pd/C in methanol P=760.051 Torr;
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: 64 percent / Et3N / tetrahydrofuran / 12 h / 20 °C 2: 75 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: 60 percent / HCl(g) / 6 h / Heating 2: 64 percent / Et3N / tetrahydrofuran / 12 h / 20 °C 3: 75 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: 93 percent / Br2; aq. KOH / 3 h / 60 °C 2: 60 percent / HCl(g) / 6 h / Heating 3: 64 percent / Et3N / tetrahydrofuran / 12 h / 20 °C 4: 75 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
