3-甲基苯噻吩-2-羧酸甲酯合成路线 （共 10 条）
反应条件
sodium hydride in tetrahydrofuran T=40°C; 3 h;
参考文献
Hong, Yong Rae; Kim, Hyun Tae; Lee, Seung-Chul; Ro, Seonggu; Cho, Joong Myung; Kim, In Su; Jung, Young Hoon
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5953 - 5957
反应条件
1: 2-mercaptoacetic acid methyl ester With sodium hydride in tetrahydrofuran; dimethyl sulfoxide T=20°C; Inert atmosphere; 2: 2-Fluoro-1-phenylethan-1-one in tetrahydrofuran; dimethyl sulfoxide T=20°C; 1 h;
参考文献
Nippon Chemiphar Co., Ltd.
Patent: EP2277874 A1, 2011 ;
Location in patent: Page/Page column 24 ;
反应条件
thionyl chloride 4 h; Reflux;
参考文献
US2011/28507 A1, ;
Page/Page column 24-25 ;
反应条件
in methanol; benzene 8 h; Irradiation;
参考文献
Sasaki, Tadashi; Hayakawa, Kenji; Ban, Hiroshi
Tetrahedron, 1982 , vol. 38, # 1 p. 85 - 91
反应条件
in methanol; benzene Irradiation;
参考文献
Sasaki, Tadashi; Hayakawa, Kenji
Tetrahedron Letters, 1980 , vol. 21, p. 1525 - 1526
反应条件
1: 94 percent / Et3N / CH2Cl2 / 0 deg C then up to room temp. 2: 66 percent / benzene; methanol / 8 h / Irradiation View Scheme
参考文献
Tetrahedron, , vol. 38, # 1 p. 85 - 91
反应条件
1: 94 percent / Et3N / CH2Cl2 / 0 deg C then up to room temp. 2: 66 percent / benzene; methanol / 8 h / Irradiation View Scheme
参考文献
Tetrahedron, , vol. 38, # 1 p. 85 - 91
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=0 - 20°C; 18 h; Inert atmosphere;
参考文献
VANDERBILT UNIVERSITY; LEE, Taekyu; PELZ, Nicholas F.; BELMAR, Johannes; BIAN, Zhiguo; OLEJNICZAK, Edward T.; FESIK, Stephen W.; CHAUDER, Brian A.
Patent: WO2014/47427 A2, 2014 ;
Location in patent: Page/Page column 233 ;
参考文献
Annali di Chimica (Rome, Italy), , vol. 43, p. 323,328
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=20°C; 4 h;
参考文献
VANDERBILT UNIVERSITY; LEE, Taekyu; PELZ, Nicholas F.; BELMAR, Johannes; BIAN, Zhiguo; OLEJNICZAK, Edward T.; FESIK, Stephen W.; CHAUDER, Brian A.
Patent: WO2014/47427 A2, 2014 ;
Location in patent: Page/Page column 233 ;
