4,6-二氯-2-(甲巯基)嘧啶-5-甲酸合成路线 （共 7 条）
反应条件
1: 4,6-dichloropyrimidine-2-(methylthio)pyrimidine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: carbon dioxide in tetrahydrofuran 0.5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 16 p. 4642 - 4646
反应条件
sodium chlorite; aminosulfonic acid in tetrahydrofuran; water; tert-butyl alcohol T=-10 - 35°C; 0.166667 h;
参考文献
EP2471793 A1, ;
Page/Page column 58 ;
反应条件
1.1: trichlorophosphate / 4 h / 120 °C 2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C 2.2: 0.5 h / 20 °C 2.3: 20 °C / pH 1 View Scheme
反应条件
1: With thionyl chloride 1 h; Reflux; 2: With ammonia in tetrahydrofuran; water T=0 - 20°C; 2 h;
参考文献
ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; WU, Fengchun; SHEN, Yan; LIU, Cuihua; ZOU, Zhenguang
Patent: WO2012/97478 A1, 2012 ;
Location in patent: Page/Page column 59-60 ;
反应条件
1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 10 - 35 °C 2: triethylamine / 2 h / 10 - 35 °C View Scheme
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2471793 A1, 2012 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=0 - 20°C; 2.5 h;
参考文献
Seto, Shigeki; Kohno, Yasushi
Heterocycles, 2009 , vol. 78, # 9 p. 2263 - 2275
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 4 h;
参考文献
Seto, Shigeki; Okada, Kyoko; Kiyota, Koichi; Isogai, Shigeki; Iwago, Maki; Shinozaki, Takehiro; Kitamura, Yoshiaki; Kohno, Yasushi; Murakami, Koji
Journal of Medicinal Chemistry, 2010 , vol. 53, # 13 p. 5012 - 5024
