3-(1H-苯并咪唑-2-基)-4-氯-苯胺合成路线 （共 4 条）
反应条件
hydrogenchloride; tin(ll) chloride in ethanol T=40 - 80°C; 2 h; Reflux;
参考文献
Genetech, Inc.; Curis, Inc.; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2014/18368 A1, 2014 ;
Location in patent: Paragraph 0162; 0169 ;
反应条件
1: With hydrogenchloride; iron in ethanol; water 2 h; Reflux; 2: With potassium carbonate in water; ethyl acetate
参考文献
Buettner, Anita; Seifert, Katrin; Cottin, Thomas; Sarli, Vasiliki; Tzagkaroulaki, Lito; Scholz, Stefan; Giannis, Athanassios
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 14 p. 4943 - 4954
反应条件
1: acetonitrile / 1 h / 25 - 75 °C / |Inert atmosphere 2: tin(ll) chloride; hydrogenchloride / ethanol / 2 h / 40 - 80 °C / |Reflux View Scheme
反应条件
1: acetonitrile / 1 h / 25 - 75 °C / |Inert atmosphere 2: tin(ll) chloride; hydrogenchloride / ethanol / 2 h / 40 - 80 °C / |Reflux View Scheme
