2-(1-Boc-4-亚哌啶基)-2-(Cbz-氨基)乙酸甲酯合成路线 （共 3 条）
反应条件
1: H2 / [(R,R)-Me-BPE-Rh-COD]OTf / methanol / 72 h / 20 °C / 4654.33 Torr 2: 98 percent / 1N LiOH / methanol / 20 h / 20 °C 3: 82 percent / H2 / 5 percent Pd/C / ethanol; H2O / 16 h / 20 °C / 2585.74 Torr View Scheme
参考文献
Shieh, Wen-Chung; Xue, Song; Reel, Noela; Wu, Raeann; Fitt, John; Repic, Oljan
Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2421 - 2425
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; P=2327.23 Torr; 12 h;
参考文献
Pikul; Ohler; Ciszewski; Laufersweiler; Almstead; De; Natchus; Hsieh; Janusz; Peng; Branch; King; Taiwo; Mieling
Journal of Medicinal Chemistry, 2001 , vol. 44, # 16 p. 2499 - 2502
反应条件
1: H2 / [(R,R)-Me-BPE-Rh-COD]OTf / methanol / 72 h / 20 °C / 4654.33 Torr
2: 98 percent / 1N LiOH / methanol / 20 h / 20 °C
View Scheme
参考文献
Shieh, Wen-Chung; Xue, Song; Reel, Noela; Wu, Raeann; Fitt, John; Repic, Oljan
Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2421 - 2425
