1-三甲苯-(R)-3-甲基哌嗪合成路线 （共 3 条）
反应条件
triethylamine in dichloromethane; acetonitrile T=20 - 30°C; 1.5 h;
参考文献
BIOVITRUM AB
Patent: WO2004/829 A1, 2003 ;
Location in patent: Page 26 ;
WO 2004/000829 A1
反应条件
potassium hydroxide; potassium carbonate in dichloromethane; water
参考文献
US6465467 B1, ;
US 6465467 B1
反应条件
1: 70.8 percent / K2CO3 / dimethylformamide / 20 h / 100 - 110 °C 2: 10 percent aq. HCl / ethanol / 0.5 h View Scheme
参考文献
Felicini; Fontana; Giribone; Nilsson; Oesterlund; Paptchikhine
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 1 p. 85 - 92
