(R)-2-氯-3-(2-甲基哌嗪-1-基)吡嗪合成路线 （共 4 条）
反应条件
sulfuric acid in water; isopropyl alcohol T=77 - 83°C; 0.5 h;
参考文献
BIOVITRUM AB
Patent: WO2004/829 A1, 2003 ;
Location in patent: Page 28-29 ;
WO 2004/000829 A1
反应条件
1: CH2Cl2 / 0.75 h 2: 70.8 percent / K2CO3 / dimethylformamide / 20 h / 100 - 110 °C 3: 10 percent aq. HCl / ethanol / 0.5 h View Scheme
参考文献
Felicini; Fontana; Giribone; Nilsson; Oesterlund; Paptchikhine
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 1 p. 85 - 92
反应条件
1: 70.8 percent / K2CO3 / dimethylformamide / 20 h / 100 - 110 °C 2: 10 percent aq. HCl / ethanol / 0.5 h View Scheme
参考文献
Felicini; Fontana; Giribone; Nilsson; Oesterlund; Paptchikhine
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 1 p. 85 - 92
反应条件
hydrogenchloride in water; ethyl acetate
T=72°C; 0.166667 h;
参考文献
BIOVITRUM AB
Patent: WO2004/829 A1, 2003 ;
Location in patent: Page 29-30 ;
WO 2004/000829 A1
