N-1-苄基-3-甲基哌嗪合成路线 （共 7 条）
反应条件
sodium hydrogencarbonate in ethanol 12 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; FIEGEN, Dennis; FLECK, Martin; HOFFMANN, Matthias; KLICIC, Jasna; EAST, Stephen, Peter; NAPIER, Spencer, Charles, R.; SCOTT, John
Patent: WO2012/101013 A1, 2012 ;
Location in patent: Page/Page column 91 ;
WO 2012/101013 A1
反应条件
sodium hydrogencarbonate in ethanol 12 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; Dahmann, Georg; Fiegen, Dennis; Fleck, Martin; Hoffmann, Matthias; Klicic, Jasna; East, Stephen Peter; Napier, Spencer Charles R.; Scott, John
Patent: US2013/23502 A1, 2013 ;
Location in patent: Paragraph 0230-0232 ;
反应条件
sodium iodide in sodium hydroxide; butanone
参考文献
US5447931 A1, ;
US 5447931 A
反应条件
hydrogen; 5 palladium over charcoal in water T=40°C; 6 h;
参考文献
EP1640364 A1, ;
Page/Page column 11-12 ;
反应条件
1: in dichloromethane T=20°C; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/135427 A1, 2007 ;
Location in patent: Page/Page column 31 ;
WO 2007/135427 A1
参考文献
Janssen Pharmaceutica N.V.
Patent: US4880808 A1, 1989 ;
反应条件
in dichloromethane T=23°C; 48 h; aminomethyl polystyrene resin; Inert atmosphereResolution of racemate;
参考文献
Kreituss, Imants; Murakami, Yuta; Binanzer, Michael; Bode, Jeffrey W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 42 p. 10660 - 10663
Angew. Chem., 2012 , vol. 124, # 42 p. 10815 - 10819,5
