1-甲氧基-2,5-二甲基-4-硝基苯合成路线 （共 7 条）
反应条件
nitric acid; sodium nitrite T=0 - 5°C; 6.33 h;
参考文献
GLAXOSMITHKLINE LLC; SCHULZ, Mark, James; WANG, Yonghui
Patent: WO2010/59549 A1, 2010 ;
Location in patent: Page/Page column 19 ;
WO 2010/059549 A1
反应条件
sodium hydroxide in water T=40 - 45°C; 2 h;
参考文献
Flitsch; Russkamp
1985 , vol. 1985, # 7 p. 1398 - 1412
反应条件
1: sodium nitrite, conc. H2SO4 / acetic acid; H2O / 0.17 h / 8 - 10 °C 2: 68percent HNO3 / H2O / 0.25 h / 45 °C 3: 58 percent / NaOH / H2O / 2 h / 40 - 45 °C View Scheme
参考文献
Flitsch; Russkamp
1985 , vol. 1985, # 7 p. 1398 - 1412
反应条件
1: 68percent HNO3 / H2O / 0.25 h / 45 °C 2: 58 percent / NaOH / H2O / 2 h / 40 - 45 °C View Scheme
参考文献
Flitsch; Russkamp
1985 , vol. 1985, # 7 p. 1398 - 1412
反应条件
sodium hydroxide; tert-butyl alcohol in water Irradiation; Quantum yield;
参考文献
Sawaura, Masaki; Mukai, Toshio
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 10 p. 3213 - 3214
反应条件
1: dimethylformamide / 96 h / 130 - 150 °C 2: 0.25 g / glacial CH3COOH, Fe / ethanol / 0.5 h / Heating View Scheme
参考文献
Glennon, R. A.; Schubert, E.; Jacyno, J. M.; Rosecrans, J. A.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1222 - 1226
反应条件
sodium hydroxide; potassium tert-butylate; dihydrogen peroxide
1) benzene; 24h, reflux; 24h, r.t.; Yield given. Multistep reaction;
参考文献
Flitsch; Russkamp
1985 , vol. 1985, # 7 p. 1398 - 1412
