2-氨基-6-三氟甲基苯甲酸合成路线 （共 4 条）
反应条件
sodium hydroxide; dihydrogen peroxide
参考文献
Journal of Organic Chemistry, , vol. 17, p. 149,153
反应条件
1: With sodium hydroxide; water in isopropyl alcohol T=83.1°C; 48 h; Heating / reflux; 2: With hydrogenchloride in water; isopropyl alcohol T=30.5°C; pH=1 - 3;
参考文献
WO2007/4735 A1, ;
Page/Page column 12-13 ;
反应条件
in tetrahydrofuran; water
6 h; Heating / reflux;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1900733 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
in toluene
3 h; Heating / reflux;
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: WO2004/4733 A1, 2004 ;
Location in patent: Page/Page column 22 ;
WO 2004/004733 A1
