6-氯-β-氧代-3-吡啶丙腈合成路线 （共 1 条）
反应条件
1: (1-(tert-butoxycarbonyl)-(4S)-fluoro-(2R)-pyrrolidinyl)acetonitrile With sodium hydride in tetrahydrofuran T=0°C; 0.75 h; 2: (6-chloro-pyridin-3-yl)-imidazol-1-yl-methanone in tetrahydrofuran T=-78 - 20°C; 3: With sodium hydrogen sulphate; water in tetrahydrofuran; ethyl acetate
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: WO2008/71451 A1, 2008 ;
Location in patent: Page/Page column 49 ;
WO 2008/071451 A1
