4-氟-2-甲氧基-5-甲基苯胺合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr;
参考文献
The Institute for Pharmaceutical Discovery LLC
Patent: US6420426 B1, 2002 ;
反应条件
1: 76 percent / pyridine; HF-pyridine; sodium nitrite / -70 - 60 °C 2: 99 percent / H2 / Pd-C / ethanol / 760 Torr View Scheme
参考文献
Van Zandt, Michael C.; Sibley, Evelyn O.; McCann, Erin E.; Combs, Kerry J.; Flam, Brenda; Sawicki, Diane R.; Sabetta, Al; Carrington, Anne; Sredy, Janet; Howard, Eduardo; Mitschler, Andre; Podjarny, Alberto D.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5661 - 5675
反应条件
sodium nitrite; copper(I) bromide in n-heptane; hydrogen bromide; ethyl acetate
参考文献
The Institute for Pharmaceutical Discovery LLC
Patent: US6420426 B1, 2002 ;
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite T=110°C; 2.5 h;
参考文献
Van Zandt, Michael C.; Sibley, Evelyn O.; McCann, Erin E.; Combs, Kerry J.; Flam, Brenda; Sawicki, Diane R.; Sabetta, Al; Carrington, Anne; Sredy, Janet; Howard, Eduardo; Mitschler, Andre; Podjarny, Alberto D.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5661 - 5675
