1: iodotrimethylsilane (TMSI) / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 2 h / 25 - 30 °C 2: 1.) pyridine, 2.) MeOH / 1.) freon TF, CH2Cl2, from 0 to 5 deg C, 30 min, 2.) from 0 to 5 deg, 10 min View Scheme

1: iodotrimethylsilane (TMSI) / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 2 h / 25 - 30 °C 2: 1.) pyridine, 2.) MeOH / 1.) freon TF, CH2Cl2, from 0 to 5 deg C, 30 min, 2.) from 0 to 5 deg, 10 min View Scheme

1: iodotrimethylsilane (TMSI) / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 2 h / 25 - 30 °C 2: 1.) pyridine, 2.) MeOH / 1.) freon TF, CH2Cl2, from 0 to 5 deg C, 30 min, 2.) from 0 to 5 deg, 10 min View Scheme

1: iodotrimethylsilane (TMSI) / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 2 h / 25 - 30 °C 2: 2.) MeOH / 1.) CH2Cl2, from 0 to 5 deg C, 3.5 h, 2.) from 0 to 5 deg C, 10 min View Scheme

methanol; trimethylsilyl iodide; hydrogen iodide 1.) freon TF, a.) from 0 to 5 deg C, b.) from 35 to 36 deg C, 51 h, 2.) from 0 to 5 deg C, 15 min; Yield given. Multistep reaction. Yields of byproduct given;