3,5-二溴-2-羟基苯甲酸合成路线 （共 79 条）
参考文献
Ullmann; Kopetschni
Chemische Berichte, 1911 , vol. 44, p. 427
反应条件
im Sonnenlicht; bei der Destillation des Reaktionsprodukts mit Baryt.Irradiation;
参考文献
Cahours
Annales de Chimie (Cachan, France), 1845 , vol. <3> 13, p. 102
Justus Liebigs Annalen der Chemie, 1844 , vol. 52, p. 338
参考文献
Zhang, Wei; Zheng, Suqing; Liu, Na; Werness, Jenny B.; Guzei, Llia A.; Tang, Weiplng
Journal of the American Chemical Society, 2010 , vol. 132, # 11 p. 3664 - 3665
反应条件
1: petroleum ether; PCl5 View Scheme
参考文献
Anschuetz,R.; Robitsek
Justus Liebigs Annalen der Chemie, 1906 , vol. 346, p. 325
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 25 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran / 0 - 25 °C / Inert atmosphere View Scheme
参考文献
Garner, Amanda L.; Gloeckner, Christian; Tricoche, Nancy; Zakhari, Joseph S.; Samje, Moses; Cho-Ngwa, Fidelis; Lustigman, Sara; Janda, Kim D.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 11 p. 3963 - 3972
参考文献
Robertson
Journal of the Chemical Society, 1902 , vol. 81, p. 1480
反应条件
1: fuming sulfuric acid; bromine
2: aqueous acetic acid; bromine / 60 °C
View Scheme
参考文献
Farinholt; Stuart; Twiss
Journal of the American Chemical Society, 1940 , vol. 62, p. 1237,1240
反应条件
phosphorus trichoride in chlorobenzene
3 h; Heating;
参考文献
Waisser, Karel; Hladuvkova, Jana; Gregor, Jiri; Rada, Tomas; Kubicova, Lenka; Klimesova, Vera; Kaustova, Jarmila
Archiv der Pharmazie, 1998 , vol. 331, # 1 p. 3 - 6
反应条件
1: 80 percent / PCl3 / xylene / 4 h / 140 °C
2: 59 percent / 2 N NaOH / bis-(2-methoxy-ethyl) ether / 2 h / 90 °C
View Scheme
参考文献
Ozawa; Takeuchi; Yamamoto; Hamada; Ito; Kuwahara; Takagaki
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 305 - 312
反应条件
phosphorus trichoride in xylene
T=140°C; 4 h;
参考文献
Ozawa; Takeuchi; Yamamoto; Hamada; Ito; Kuwahara; Takagaki
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 305 - 312
