1,2,4-哌嗪三羧酸,4-(1,1-二甲基乙基)2-甲基1-(苯基甲基)酯,(2S)-合成路线 （共 6 条）
反应条件
methanol in toluene T=20°C;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; BRANCA, Danila; FERRIGNO, Federica; HERNANDO, Jose, Ignacio, Martin; JONES, Philip; KINZEL, Olaf; MALANCONA, Savina; MURAGLIA, Ester; PALUMBI, Maria, Cecilia; PESCATORE, Giovanna; SCARPELLI, Rita
Patent: WO2010/23480 A1, 2010 ;
Location in patent: Page/Page column 41 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
Blizzard, Timothy A.; Singh, Sanjay; Patil, Basanagoud; Chidurala, Naresh; Komanduri, Venukrishnan; Debnath, Samarpita; Belyakov, Sergei; Crespo, Alejandro; Struck, Alice; Kurtz, Marc; Wiltsie, Judyann; Shen, Xun; Sonatore, Lisa; Arocho, Marta; Lewis, Dale; Ogletree, Martin; Biftu, Tesfaye
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1111 - 1115
反应条件
1.1: sodium hydrogencarbonate / water; 1,4-dioxane / 16 h / 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C 2.2: 2 h / 20 °C View Scheme
参考文献
Blizzard, Timothy A.; Singh, Sanjay; Patil, Basanagoud; Chidurala, Naresh; Komanduri, Venukrishnan; Debnath, Samarpita; Belyakov, Sergei; Crespo, Alejandro; Struck, Alice; Kurtz, Marc; Wiltsie, Judyann; Shen, Xun; Sonatore, Lisa; Arocho, Marta; Lewis, Dale; Ogletree, Martin; Biftu, Tesfaye
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1111 - 1115
反应条件
1.1: sodium hydrogencarbonate / water; 1,4-dioxane / 16 h / 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C 2.2: 2 h / 20 °C View Scheme
参考文献
Blizzard, Timothy A.; Singh, Sanjay; Patil, Basanagoud; Chidurala, Naresh; Komanduri, Venukrishnan; Debnath, Samarpita; Belyakov, Sergei; Crespo, Alejandro; Struck, Alice; Kurtz, Marc; Wiltsie, Judyann; Shen, Xun; Sonatore, Lisa; Arocho, Marta; Lewis, Dale; Ogletree, Martin; Biftu, Tesfaye
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1111 - 1115
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 3 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; BRANCA, Danila; FERRIGNO, Federica; HERNANDO, Jose, Ignacio, Martin; JONES, Philip; KINZEL, Olaf; MALANCONA, Savina; MURAGLIA, Ester; PALUMBI, Maria, Cecilia; PESCATORE, Giovanna; SCARPELLI, Rita
Patent: WO2010/23480 A1, 2010 ;
Location in patent: Page/Page column 41 ;
反应条件
1: With trifluoroacetic acid 2 h; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
EP1187828 B1, ;
Page 19 ;
