1,3-二甲基-2-喹噁啉酮合成路线 （共 22 条）
反应条件
1: 50 percent / H2O; dimethylformamide / 2 h / 20 - 25 °C 2: 30 percent / HCl / aq. HCl / 5 h View Scheme
参考文献
Essassi, El Mokhtar; Ferfra, Souad; Salem, Moussa; Zniber, Rachid
Bulletin des Societes Chimiques Belges, 1990 , vol. 99, # 1 p. 47 - 60
反应条件
1: 80 percent / Br2, NaOAc / acetic acid / 1 h / Ambient temperature 2: 50 percent / H2O; dimethylformamide / 2 h / 20 - 25 °C 3: 30 percent / HCl / aq. HCl / 5 h View Scheme
参考文献
Essassi, El Mokhtar; Ferfra, Souad; Salem, Moussa; Zniber, Rachid
Bulletin des Societes Chimiques Belges, 1990 , vol. 99, # 1 p. 47 - 60
反应条件
diazomethane; methanol
参考文献
Cheeseman
Journal of the Chemical Society, 1955 , p. 1804,1806
反应条件
diazomethane; methanol
参考文献
Cheeseman
Journal of the Chemical Society, 1955 , p. 1804,1806
Full Text Show Details
Ohle et al.
Chemische Berichte, 1937 , vol. 70, p. 2148,2152
反应条件
in methanol Ambient temperature;
参考文献
Duffy, Kevin J.; Haltiwanger, R. Curtius; Huang, Yifang; Konialian-Beck, Arda; Luengo, Juan I.
Tetrahedron Letters, 1998 , vol. 39, # 44 p. 8017 - 8020
参考文献
Kehrmann; Messinger
Chemische Berichte, 1892 , vol. 25, p. 1627
Full Text Show Details
Messinger; Kehrmann
Patent: DE64923 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 989
参考文献
Cook; Perry
Journal of the Chemical Society, 1943 , p. 394,396
反应条件
sodium hydride 5 min., room temp.; Multistep reaction;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 51, # 2 p. 419 - 428
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 10.5 h; Heating;
参考文献
Lawrence; Copper; Smith
Journal of Medicinal Chemistry, 2001 , vol. 44, # 4 p. 594 - 601
反应条件
bromine in acetic acid T=20°C; 2.16667 h;
参考文献
ACTELION PHARMACEUTICALS LTD; FISCHLI, Walter
Patent: WO2004/96780 A1, 2004 ;
Location in patent: Page 20 ;
WO 2004/096780 A1
