2-三氧代-3-(3-三氟亚甲苯)-噻唑烷-4-酮合成路线 （共 5 条）
反应条件
1: With triethylamine in tetrahydrofuran; water T=0 - 20°C; 3.5 h; 2: With hydrogenchloride in tetrahydrofuran; water Reflux;
参考文献
US2011/105565 A1, ;
Page/Page column 26-28 ;
反应条件
1: With sodium hydrogencarbonate T=20°C; pH=8 - 9; 2 h; 2: With hydrogenchloride in water Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 16, # 17 p. 8187 - 8195
反应条件
in water T=95 - 100°C;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 24 p. 7843 - 7854
反应条件
1.1: triethylamine / ethyl acetate / Cooling with ice 2.1: sodium hydrogencarbonate / water / 2 h / pH 8 - 9 2.2: Reflux View Scheme
反应条件
piperidine in ethanol Knoevenagel condensation; 2 h; Reflux;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: US2011/105565 A1, 2011 ;
Location in patent: Page/Page column 28 ;
