1,3,5-三氟-2-硝基苯合成路线 （共 25 条）
反应条件
1: With sodium methylate T=20°C; 2: With hydrogen; palladium 10 on activated carbon in methanol T=20°C;
参考文献
BAYER AKTIENGESELLSCHAFT
Patent: WO2003/76405 A1, 2003 ;
Location in patent: Page/Page column 85 ;
反应条件
1: With methanol T=20°C; 18 h; 2: With palladium 10 on activated carbon; hydrogen in methanol T=20°C; 18 h;
参考文献
VIVALIS; GUEDAT, Philippe; BERECIBAR, Amaya; CIAPETTI, Paola; VENKATA PITHANI, Subhash; TROUCHE, Nathalie
Patent: WO2013/171281 A1, 2013 ;
Location in patent: Page/Page column 156 ;
反应条件
1: methanol 2: NaBH4, Pd/C / ethanol View Scheme
参考文献
Barnard; Storr; O'Neill; Park
Journal of Pharmacy and Pharmacology, 1993 , vol. 45, # 8 p. 736 - 744
反应条件
sodium hydroxide in water; dimethyl sulfoxide
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1346982 A1, 2003 ;
反应条件
1: With sodium hydroxide in water; dimethyl sulfoxide T=20°C; 20 h; 2: With hydrogenchloride in water pH=5;
参考文献
AstraZeneca AB
Patent: US6441012 B1, 2002 ;
US 6441012 B1
反应条件
sodium hydroxide in dimethyl sulfoxide
参考文献
Levy, Louis A.; Gabel, Scott A.; London, Robert E.
Magnetic Resonance in Chemistry, 1996 , vol. 34, # 6 p. 440 - 446
反应条件
sodium methylate; boron tribromide 1.) MeOH, 2.) CH2Cl2; Multistep reaction;
参考文献
O'Neill, Paul M.; Harrison, Anthony C.; Storr, Richard C.; Hawley, Shaun R.; Ward, Stephen A.; Park, B. Kevin
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1362 - 1370
反应条件
boron tribromide 1.) methanol, 2 h, 2.) dichloromethane, RT, overnight; Yield given. Multistep reaction;
参考文献
Barnard; Storr; O'Neill; Park
Journal of Pharmacy and Pharmacology, 1993 , vol. 45, # 8 p. 736 - 744
反应条件
sodium amide in ammonia T=-70°C; 3 h;
参考文献
Selivanova, G. A.; Chuikova, T. V.; Shtark, A. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 12 p. 2267 - 2272
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 12 p. 2513 - 2518
参考文献
Barnard; Storr; O'Neill; Park
Journal of Pharmacy and Pharmacology, 1993 , vol. 45, # 8 p. 736 - 744
