1,3,5-三氟-2-硝基苯合成路线 （共 25 条）
反应条件
sodium methylate; boron tribromide
1.) MeOH, 2.) CH2Cl2; Multistep reaction;
参考文献
O'Neill, Paul M.; Harrison, Anthony C.; Storr, Richard C.; Hawley, Shaun R.; Ward, Stephen A.; Park, B. Kevin
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1362 - 1370
反应条件
sulfuric acid; periodic acid; potassium iodide
T=0 - 50°C; 4 h;
参考文献
Sander, Wolfram; Winkler, Michael; Cakir, Bayram; Grote, Dirk; Bettinger, Holger F.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 715 - 724
反应条件
1: 89 percent / H5IO6; H2SO4; KI / 4 h / 0 - 50 °C
2: 86 percent / hydrogen / palladium on carbon / methanol / 1 h / 3000.24 Torr
View Scheme
参考文献
Sander, Wolfram; Winkler, Michael; Cakir, Bayram; Grote, Dirk; Bettinger, Holger F.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 715 - 724
反应条件
1: 89 percent / H5IO6; H2SO4; KI / 4 h / 0 - 50 °C
2: 86 percent / hydrogen / palladium on carbon / methanol / 1 h / 3000.24 Torr
3: 650 mg / trifluoroacetic acid; sodium nitrite / H2O / 0.5 h / -5 °C
View Scheme
参考文献
Sander, Wolfram; Winkler, Michael; Cakir, Bayram; Grote, Dirk; Bettinger, Holger F.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 715 - 724
反应条件
trifluorormethanesulfonic acid; Boron tris(trifluoromethanesulfonate); nitric acid
T=20°C; 4 h;
参考文献
Olah, George A.; Orlinkov, Alexander; Oxyzoglou, Alexandros B.; Prakash, G. k. Surya
Journal of Organic Chemistry, 1995 , vol. 60, # 22 p. 7348 - 7350
