Alpha-甲基苯乙酸甲酯合成路线 （共 146 条）
反应条件
sodium hydroxide; horse liver esterase in water Ambient temperaturepH 7.2; the efficiency of this enzymatic resolution was studied also by using other substrates; other enzym: pig liver esterase; Product distribution;
参考文献
Ahmar, M.; Girard, C.; Bloch, R.
Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7053 - 7056
反应条件
sodium hydroxide in water T=40°C; 1.25 h; titrisol buffer pH 8, carboxylesterase NP; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Iriuchijima, Shinobu; Keiyu, Atsuko
Agricultural and Biological Chemistry, 1981 , vol. 45, # 6 p. 1389 - 1392
反应条件
Novozym 435; water in tert-butyl methyl ether T=45°C; Kinetics; SolventConcentration; optical yield given as percent ee;
参考文献
Wang, Pei-Yun; Chen, Ying-Ju; Wu, An-Chi; Lin, Yi-Sheng; Kao, Min-Fang; Chen, Jin-Ru; Ciou, Jyun-Fen; Tsai, Shau-Wei
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 14-15 p. 2333 - 2341
反应条件
sodium hydroxide; horse liver esterase in water Ambient temperaturepH 7.2; the efficiency of this enzymatic resolution was studied also by using other substrates; other enzym: pig liver esterase; Product distribution;
参考文献
Ahmar, M.; Girard, C.; Bloch, R.
Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7053 - 7056
反应条件
1: 94.8 percent / LiAlH4 / diethyl ether / 1.17 h / Ambient temperature 2: 97.2 percent / pyridine / 22.5 h / Ambient temperature 3: 0.1 M phosphate buffer (pH 7.0) / methanol / 2 h / 35 - 36 °C / lipase PRL-Sigma L-3126 View Scheme
参考文献
Matsumoto; Takeda; Iwata; Sakamoto; Ishida
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 6 p. 1191 - 1197
反应条件
(i) NaNH2, liq. NH3, (ii) /BRN= 969135/; Multistep reaction;
参考文献
Toray Industries, Inc.
Patent: US4775692 A1, 1988 ;
反应条件
1: 1.) NaH / 1.) 1,2-dimethoxyethane, reflux, 5 h, 2.) 1,2-dimethoxyethane, reflux, 15 h 2: tributyltin hydride, AIBN / benzene / 4 h / Heating View Scheme
参考文献
Tada, Masaru; Akinaga, Shiro; Okabe, Masami
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 12 p. 3939 - 3940
反应条件
1: 94.8 percent / LiAlH4 / diethyl ether / 1.17 h / Ambient temperature 2: 97.2 percent / pyridine / 22.5 h / Ambient temperature 3: 0.1 M phosphate buffer (pH 7.0) / methanol / 2 h / 35 - 36 °C / lipase PRL-Sigma L-3126 View Scheme
参考文献
Matsumoto; Takeda; Iwata; Sakamoto; Ishida
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 6 p. 1191 - 1197
反应条件
1: 94.8 percent / LiAlH4 / diethyl ether / 1.17 h / Ambient temperature 2: 97.2 percent / pyridine / 22.5 h / Ambient temperature View Scheme
参考文献
Matsumoto; Takeda; Iwata; Sakamoto; Ishida
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 6 p. 1191 - 1197
参考文献
Greene
Journal of the American Chemical Society, 1959 , vol. 81, p. 2688,2690
