1-(2,6-二氯苄基)-3-吡咯烷-1-甲基-1H-吲唑-6-胺合成路线 （共 4 条）
反应条件
iron(III) chloride; carbon; N1,N1-dimethylhydrazine in methanol 2 h; Heating;
参考文献
Zhang; Derian; Andrade-Gordon; Hoekstra; McComsey; White; Poulter; Addo; Cheung; Damiano; Oksenberg; Reynolds; Pandey; Scarborough; Maryanoff
Journal of Medicinal Chemistry, 2001 , vol. 44, # 7 p. 1021 - 1024
反应条件
1: aq. sodium nitrite / 4 h 2: 5.14 g / AcOH; NaBH(OAc)3 / 1,2-dichloro-ethane; dimethylformamide / 2 h / 20 °C 3: 2.4 g / KOH / tetrahydrofuran / 1 h / 20 °C 4: 1.75 g / ferric chloride hexahydrate; activated charcoal; 1,1-dimethylhydrazine / methanol / 2 h / Heating View Scheme
参考文献
Zhang; Derian; Andrade-Gordon; Hoekstra; McComsey; White; Poulter; Addo; Cheung; Damiano; Oksenberg; Reynolds; Pandey; Scarborough; Maryanoff
Journal of Medicinal Chemistry, 2001 , vol. 44, # 7 p. 1021 - 1024
反应条件
1: 5.14 g / AcOH; NaBH(OAc)3 / 1,2-dichloro-ethane; dimethylformamide / 2 h / 20 °C 2: 2.4 g / KOH / tetrahydrofuran / 1 h / 20 °C 3: 1.75 g / ferric chloride hexahydrate; activated charcoal; 1,1-dimethylhydrazine / methanol / 2 h / Heating View Scheme
参考文献
Zhang; Derian; Andrade-Gordon; Hoekstra; McComsey; White; Poulter; Addo; Cheung; Damiano; Oksenberg; Reynolds; Pandey; Scarborough; Maryanoff
Journal of Medicinal Chemistry, 2001 , vol. 44, # 7 p. 1021 - 1024
反应条件
1: 2.4 g / KOH / tetrahydrofuran / 1 h / 20 °C 2: 1.75 g / ferric chloride hexahydrate; activated charcoal; 1,1-dimethylhydrazine / methanol / 2 h / Heating View Scheme
参考文献
Zhang; Derian; Andrade-Gordon; Hoekstra; McComsey; White; Poulter; Addo; Cheung; Damiano; Oksenberg; Reynolds; Pandey; Scarborough; Maryanoff
Journal of Medicinal Chemistry, 2001 , vol. 44, # 7 p. 1021 - 1024
