hydrogen; palladium on activated charcoal; ethylenediamine in methanol T=20°C; Hydrogenolysis; P=760 Torr; 0.75 h;

sodium hydroxide in tetrahydrofuran; ethyl acetate

1: tetrahydrofuran / 20 h / 20 °C 2: 66 percent / PCC/SiO2 / CH2Cl2 / 4 h / 20 °C 3: 74 percent / tetrahydrofuran / 43 h / Heating 4: 64 percent Spectr. / H2 / Pd/C-ethylenediamine / methanol / 0.75 h / 20 °C / 760 Torr View Scheme

1: 66 percent / PCC/SiO2 / CH2Cl2 / 4 h / 20 °C 2: 74 percent / tetrahydrofuran / 43 h / Heating 3: 64 percent Spectr. / H2 / Pd/C-ethylenediamine / methanol / 0.75 h / 20 °C / 760 Torr View Scheme

1: 74 percent / tetrahydrofuran / 43 h / Heating 2: 64 percent Spectr. / H2 / Pd/C-ethylenediamine / methanol / 0.75 h / 20 °C / 760 Torr View Scheme

hydrogen; palladium on activated charcoal; ethylenediamine in 1,4-dioxane T=20°C; Hydrogenation; P=760 - 3800 Torr; Product distributionKinetics; Further Variations:SolventsPressures;