2,4-二氟-5-甲基苯甲醛合成路线 （共 4 条）
反应条件
magnesium in tetrahydrofuran T=0°C;
参考文献
Shibata, Norio; Das, Biplab Kumar; Takeuchi, Yoshio
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 24 p. 4234 - 4236
反应条件
1: 1-bromo-2,4-difluoro-5-methylbenzene With iodine; magnesium in tetrahydrofuran T=20°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0 - 20°C; 4.75 h;
参考文献
Das, Biplab Kumar; Shibata, Norio; Takeuchi, Yoshio
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 197 - 206
反应条件
in tetrahydrofuran; diethyl ether T=25°C; Grignard reaction; 0.5 h;
参考文献
Wang, Zhi-Xian; Duan, Weili; Wiebe, Leonard I.; De Clercq, Erik; Balzarini, Jan; Knaus, Edward E.
Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 9 p. 1397 - 1411
反应条件
diisobutylaluminium hydride in tetrahydrofuran T=-10°C; Reduction; 1 h;
参考文献
Wang, Zhi-Xian; Duan, Weili; Wiebe, Leonard I.; De Clercq, Erik; Balzarini, Jan; Knaus, Edward E.
Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 9 p. 1397 - 1411
