(2,4-二氟-5-甲基苯基)甲醇合成路线 （共 3 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78°C; 2 h; Cooling with acetone-dry ice;
参考文献
CONFLUENCE LIFE SCIENCES, INC.; SELNESS, Shaun R.; Devadas, Balekudru; Hockerman, Susan L.; Monahan, Joseph B.
Patent: US2013/143906 A1, 2013 ;
Location in patent: Paragraph 0330 ;
反应条件
diisobutylaluminium hydride in tetrahydrofuran T=-10°C; Reduction; 1 h;
参考文献
Wang, Zhi-Xian; Duan, Weili; Wiebe, Leonard I.; De Clercq, Erik; Balzarini, Jan; Knaus, Edward E.
Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 9 p. 1397 - 1411
反应条件
1: thionyl chloride / methanol / 3 h / 50 °C / |Cooling with ice 2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 °C / |Cooling with acetone-dry ice View Scheme
参考文献
CONFLUENCE LIFE SCIENCES, INC.; SELNESS, Shaun R.; Devadas, Balekudru; Hockerman, Susan L.; Monahan, Joseph B.
Patent: US2013/143906 A1, 2013 ;
