3-(4-甲氧基苯甲酰基)丙酸合成路线 （共 71 条）
反应条件
sulfuric acid in ethanol; water
参考文献
Kali-Chemie Pharma GmbH
Patent: US5324725 A1, 1994 ;
反应条件
sulfuric acid in benzene 14 h; Heating;
参考文献
Mahmoodi; Yousefi-Malekroudi
Russian Journal of Organic Chemistry, 2006 , vol. 42, # 3 p. 365 - 368
反应条件
1: 99 percent / diethyl ether
2: 92.7 percent / H2 / Pd/C / ethanol / 2585.74 Torr
3: 51 percent / POCl3 / 0 - 40 °C
4: 86.2 percent / NaBH4 / methanol / 0 - 5 °C
5: 85.6 percent / H2 / Pd/C / ethanol / 2327.17 - 2585.74 Torr
View Scheme
参考文献
Koul; Singh; Taneja; Qazi
Tetrahedron, 2003 , vol. 59, # 19 p. 3487 - 3491
反应条件
1: 71 percent / hydrazine monohydrate, KOH / bis-(2-hydroxy-ethyl) ether / a) reflux, 3 h, b) 180 deg C, 4 h
2: 91 percent / 48percent HBr, glacial AcOH / 6 h / Heating
3: DCCI / ethyl acetate / 4 h
4: NH3 (gas) / CH2Cl2 / 12 h
5: 23 percent / 2 M borane*methyl sulfide complex / tetrahydrofuran / 6 h / Heating
View Scheme
参考文献
Boden, Phil; Eden, Jon M.; Hodgson, Julie; Horwell, David C.; Hughes, John; McKnight, Alexander T.; Lewthwaite, Russell A.; Pritchard, Martyn C.; Raphy, Jenny; Meecham, Ken; Ratcliffe, Giles S.; Suman-Chauhan, Nirmala; Woodruff, Geoffrey N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1664 - 1675
反应条件
1: methanesulfonyl chloride, pyridine / 1 h / 0 °C
2: NH3(gas) / Ambient temperature
3: methanesulfonyl chloride / 2 h / 0 - 20 °C
4: 27 percent / aluminum chloride / CH2Cl2 / 20 h / Heating
View Scheme
参考文献
Dillard, Robert D.; Hahn, Richard A.; McCullough, Doris; Carr, F. Patrick; Rinkema, Lynn E.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2768 - 2778
反应条件
pyridine; lead(IV) acetate; copper diacetate
参考文献
Sane,P.P. et al.
Synthesis, 1973 , p. 541 - 542
反应条件
sodium acetate in acetic anhydride
Heating;
参考文献
El-Kousy; El-Torgoman; El-Basiouny; Hashem
Pharmazie, 1988 , vol. 43, # 2 p. 80 - 81
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / |Inert atmosphere; |Schlenk technique; |Reflux
2: toluene-4-sulfonic acid / dichloromethane / 0.25 h / 20 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
He, Ruoyu; Jin, Xiqing; Chen, Hui; Huang, Zhi-Tang; Zheng, Qi-Yu; Wang, Congyang
Journal of the American Chemical Society, 2014 , vol. 136, # 18 p. 6558 - 6561
反应条件
1: HBr, HOAc / Heating
2: NaH / dimethylformamide
3: 1.) KH / 1.) THF
4: NaOH / methanol
5: NaBH4
6: TFA / CH2Cl2
7: NaOMe / methanol
8: K2CO3 / butan-2-one / 4 h / Heating
9: NaOH / methanol; tetrahydrofuran
View Scheme
参考文献
Young; Belanger; Champion; DeHaven; Denis; Ford-Hutchinson; Fortin; Frenette; Gauthier; Gillard
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1573 - 1576
反应条件
1: 94 percent / Zn/Hg, aq. HCl / H2O; toluene / 45 h / Heating
2: 72.4 percent / H2SO4 / 9 h / Heating
3: 91.7 percent / diethyl ether / 4 h
View Scheme
参考文献
Bachule, M. T.; Mane, R. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1998 , vol. 37, # 3 p. 281 - 284
