N-FMOC-L-甘氨酸合成路线 （共 36 条）
反应条件
1: POCl3 View Scheme
参考文献
Henneke,K.-W. et al.
Liebigs Annalen der Chemie, 1979 , p. 1370 - 1387
参考文献
Kantlehner, Willi; Wagner, Fritz; Bredereck, Hellmut
Liebigs Annalen der Chemie, 1980 , # 3 p. 344 - 357
反应条件
24 h; Ambient temperature;
参考文献
Kantlehner, Willi; Wagner, Fritz; Bredereck, Hellmut
Liebigs Annalen der Chemie, 1980 , # 3 p. 344 - 357
参考文献
Kantlehner, Willi; Wagner, Fritz; Bredereck, Hellmut
Liebigs Annalen der Chemie, 1980 , # 3 p. 344 - 357
反应条件
24 h; Ambient temperature;
参考文献
Kantlehner, Willi; Wagner, Fritz; Bredereck, Hellmut
Liebigs Annalen der Chemie, 1980 , # 3 p. 344 - 357
反应条件
1: 65 percent / POCl3; i-Pr2NH / CH2Cl2 / 1 h / 0 °C 2: 70 percent / NaH / dimethylsulfoxide; diethyl ether / 1 h / Heating View Scheme
参考文献
Osipova, Anna; Yufit, Dmitrii S.; De Meijere, Armin
Synthesis, 2007 , # 1 p. 131 - 139
反应条件
sodium hydrogencarbonate
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5420275 A1, 1995 ;
反应条件
1: With potassium tert-butylate in diethyl ether T=0°C; 1.5 h; 2: With hydrogenchloride in diethyl ether; water 0.5 h; 3: With Carbamonitrile in diethyl ether; water T=100°C; 1 h;
参考文献
CENTRAX INTERNATIONAL, INC.; FAN, Xiaoqing, Michelle; CEN, Jian, James
Patent: WO2014/18807 A1, 2014 ;
Location in patent: Paragraph 00299; 00300 ;
反应条件
triethylamine; trichlorophosphate in dichloromethane T=5 - 20°C; Inert atmosphereCooling with ice;
参考文献
Matsuo, Takashi; Hayashi, Akihiro; Abe, Masato; Matsuda, Takaaki; Hisaeda, Yoshio; Hayashi, Takashi
Journal of the American Chemical Society, 2009 , vol. 131, # 42 p. 15124 - 15125
反应条件
1: glycine With ethanol 2: glicine ethyl ester hydrochloride With formic acid methyl ester 3: 2-formylaminoacetic acid ethyl ester With trichlorophosphate
参考文献
Gruenenthal GmbH
Patent: US2003/236429 A1, 2003 ;
Location in patent: Page 11 ;
