3,9-二氢-1,3-二丙基-1H-嘌呤-2,6-二酮合成路线 （共 13 条）
反应条件
sulfuric acid; methoxybenzene in trifluoroacetic acid 7 h; Heating;
参考文献
Sakai, Ryosuke; Konno, Kayo; Yamamoto, Yasunori; Sanae, Fujiko; Takagi, Kenzo; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4039 - 4044
反应条件
1: 1 h; Reflux; 2: With sodium hydroxide in ethanol; water 1 h; Reflux;
参考文献
Baraldi, Pier Giovanni; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Romagnoli, Romeo; Saponaro, Giulia; Baraldi, Stefania; Botta, Maurizio; Bernardini, Cesare; Tafi, Andrea; Tuccinardi, Tiziano; Martinelli, Adriano; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 24 p. 10281 - 10294
反应条件
1: K2CO3 / dimethylformamide / 2 h / 60 °C 2: K2CO3 / dimethylformamide / 3 h / 50 °C 3: 84 percent / conc. H2SO4, anisole / trifluoroacetic acid / 7 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 22 p. 4039 - 4044
反应条件
1: 85 percent / 2 N aq. NaOH / 1.5 h / Heating 2: K2CO3 / dimethylformamide / 2 h / 60 °C 3: K2CO3 / dimethylformamide / 3 h / 50 °C 4: 84 percent / conc. H2SO4, anisole / trifluoroacetic acid / 7 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 22 p. 4039 - 4044
反应条件
1: K2CO3 / dimethylformamide / 3 h / 50 °C 2: 84 percent / conc. H2SO4, anisole / trifluoroacetic acid / 7 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 22 p. 4039 - 4044
反应条件
T=100°C; 3 h; Inert atmosphere;
参考文献
Liu, Gang; Reddy, P.S. Murali; Barber, Jack R.; Ng, Shi Chung; Zhou, Yuefen
Synthetic Communications, 2010 , vol. 40, # 10 p. 1418 - 1436
反应条件
1.1: NH2NH2 / Pd/C 2.2: NaOH View Scheme
参考文献
Farmaco, , vol. 60, # 8 p. 643 - 651
反应条件
1: Py 2: aq. NaOH View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 466 - 469
反应条件
1.1: NaNO2; aq. HCl 2.1: NH2NH2 / Pd/C 3.2: NaOH View Scheme
参考文献
Farmaco, , vol. 60, # 8 p. 643 - 651
