3-羟基-3-苯基丁烷-2-酮合成路线 （共 33 条）
参考文献
Wegmann; Dahn
Helvetica Chimica Acta, 1946 , vol. 29, p. 101,108
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Lapkin; Golowkowa
Zhurnal Obshchei Khimii, 1949 , vol. 19, p. 701,704
J. Gen. Chem. USSR (Engl. Transl.), 1949 , vol. 19, p. 669,672
参考文献
Matsoyan,S.G. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1960 , vol. 30, # 4 p. 1202 - 1207,1223 - 1228
反应条件
diethyl ether Behandeln des erhaltenen Methylphenylhydrazons mit Wasser und Benzaldehyd;
参考文献
Diels; Johlin
Chemische Berichte, 1911 , vol. 44, p. 408
反应条件
(i) nBuLi, pentane, THF, (ii) HgCl2, CaCO3, aq. MeOH; Multistep reaction;
参考文献
Katzenellenbogen,J.A.; Bowlus,S.B.
Journal of Organic Chemistry, 1973 , vol. 38, p. 627 - 632
反应条件
Yield given. Multistep reaction;
参考文献
Baldwin, Jack E.; Adlington, Robert M.; Bottaro, Jeffrey C.; Kolhe, Jayant N.; Perry, Matthew W. D.; Jain, Ashok U.
Tetrahedron, 1986 , vol. 42, # 15 p. 4223 - 4234
反应条件
(i) Li, MeOH, (ii) /BRN= 3587162/, Et2O; Multistep reaction;
参考文献
Mizuno,H. et al.
Chemical and Pharmaceutical Bulletin, 1971 , vol. 19, p. 227 - 246
反应条件
1: TsOH / benzene / Heating 2: (i) decalin, (ii) /BRN= 471389/, Py View Scheme
参考文献
Mizuno,H. et al.
Chemical and Pharmaceutical Bulletin, 1971 , vol. 19, p. 227 - 246
反应条件
Al tri-t-BuO- in toluene T=80°C; Equilibrium constant;
参考文献
Elphimoff-Felkin,I.; Verrier,M.
Bulletin de la Societe Chimique de France, 1967 , p. 1052 - 1057
反应条件
hydrogenchloride in tetrahydrofuran; mineral oil
参考文献
American Home Products Corporation
Patent: US4169202 A1, 1979 ;
反应条件
1.1: NaH / tetrahydrofuran / 65 °C
1.2: aq. HCl / dioxane / 20 °C
2.1: LiOH*H2O / tetrahydrofuran; methanol / 20 °C
View Scheme
参考文献
Jirkovski, Ivo; Cayen, Mitchell, N.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1154 - 1156
