4-溴-2,5-二甲氧基苯甲醛合成路线 （共 16 条）
反应条件
bromine; acetic acid in water T=20°C; 12 h; regiospecific reaction;
参考文献
Koo, Ja Young; Oh, Sangmi; Cho, Seung-Rye; Koh, Minseob; Oh, Won-Keun; Choi, Hueng-Sik; Park, Seung Bum
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 35 p. 5782 - 5786
反应条件
titanium tetrachloride in dichloromethane T=-78°C; 1 h;
参考文献
Daiichi Pure Chemicals Co. Ltd.; Nagano, Tetsuo
Patent: EP1403268 A1, 2004 ;
Location in patent: Page 10 ;
反应条件
titanium tetrachloride in dichloromethane T=-78°C; 1 h;
参考文献
Maruyama, Satoko; Kikuchi, Kazuya; Hirano, Tomoya; Urano, Yasuteru; Nagano, Tetsuo
Journal of the American Chemical Society, 2002 , vol. 124, # 36 p. 10650 - 10651
反应条件
1: 2,5-dibromo-1,4-dimethoxybenzene With n-butyllithium; N,N-dimethyl-formamide in diethyl ether; hexane T=0°C; 0.416667 h; 2: N,N-dimethyl-formamide in hexane 0.166667 h; Heating; Further stages.;
参考文献
Layton, Mark E.; Morales, Carl A.; Shair, Matthew D.
Journal of the American Chemical Society, 2002 , vol. 124, # 5 p. 773 - 775
反应条件
in acetic acid T=20°C; Bromination; 72 h;
参考文献
Organic Preparations and Procedures International, , vol. 23, # 4 p. 419 - 424
反应条件
trimethylsilyl bromide; [bis(acetoxy)iodo]benzene
参考文献
Evans, P. Andrew; Brandt, Thomas A.
Journal of Organic Chemistry, 1997 , vol. 62, # 16 p. 5321 - 5326
反应条件
sodium hypochlorite; disodium hydrogenphosphate; dihydrogen peroxide in water; acetonitrile T=20°C; Inert atmosphere;
参考文献
Wang, Yizhong; Wang, Chao; Butler, John R.; Ready, Joseph M.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 41 p. 10796 - 10799
Angew. Chem., 2013 , vol. 52-41, p. 10796 - 10799,4
反应条件
1: ammonium acetate / 1.) reflux, 6 h, 2.) RT, 16 h 2: LiAlH4, H2SO4 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740
反应条件
borane dimethyl sulfide complex in chlorobenzene T=0 - 130°C; 21 h; Inert atmosphere;
参考文献
Bedford, Robin B.; Bowen, John G.; Weeks, Amanda L.
Tetrahedron, 2013 , vol. 69, # 22 p. 4389 - 4394
反应条件
1: borane dimethyl sulfide complex / chlorobenzene / 21 h / 0 - 130 °C / |Inert atmosphere
2: sodium t-butanolate; palladium diacetate; [(t-Bu)3PH]BF4 / toluene / 3 h / 160 °C / |Inert atmosphere; |Microwave irradiation
3: boron tribromide / dichloromethane / 18 h / -78 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Bedford, Robin B.; Bowen, John G.; Weeks, Amanda L.
Tetrahedron, 2013 , vol. 69, # 22 p. 4389 - 4394
