4-溴-2,5-二甲氧基苯甲醛合成路线 （共 16 条）
反应条件
sodium tetrahydroborate in methanol
T=0 - 20°C;
参考文献
Layton, Mark E.; Morales, Carl A.; Shair, Matthew D.
Journal of the American Chemical Society, 2002 , vol. 124, # 5 p. 773 - 775
反应条件
sodium hydride
1.) DMF, ice-bath, 2.) room temperature; Yield given. Multistep reaction;
参考文献
Schwartz, John A.
Synthetic Communications, 1986 , vol. 16, # 5 p. 565 - 570
反应条件
1: ammonium acetate / 1.) reflux, 8 h, 2.) RT, 60 h
2: LiAlH4, H2SO4 / tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Barfknecht; Nichols
Journal of medicinal chemistry, 1971 , vol. 14, # 4 p. 370 - 372
反应条件
1.1: m-CPBA / CH2Cl2 / 4 h / 25 °C
1.2: 99 percent / aq. NaOH / methanol / 1 h / 25 °C
2.1: 84 percent / DBU; CuCl2 / acetonitrile / 6 h / 0 °C
3.1: cerium ammonium nitrate / acetonitrile; H2O / 0.5 h / 25 °C
4.1: PhCH3 / 0.5 h / 40 °C
5.1: NaBH4; AcOH / tetrahydrofuran / 0.5 h / 25 °C
6.1: DIPEA / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Tisdale, Eric J.; Kochman, David A.; Theodorakis, Emmanuel A.
Tetrahedron Letters, 2003 , vol. 44, # 16 p. 3281 - 3284
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in dichloromethane
T=25°C; Baeyer-Villiger oxidation; 4 h;
2: With sodium hydroxide in methanol
T=25°C; 1 h;
参考文献
Tisdale, Eric J.; Kochman, David A.; Theodorakis, Emmanuel A.
Tetrahedron Letters, 2003 , vol. 44, # 16 p. 3281 - 3284
反应条件
1.1: m-CPBA / CH2Cl2 / 4 h / 25 °C
1.2: 99 percent / aq. NaOH / methanol / 1 h / 25 °C
2.1: 84 percent / DBU; CuCl2 / acetonitrile / 6 h / 0 °C
3.1: cerium ammonium nitrate / acetonitrile; H2O / 0.5 h / 25 °C
4.1: PhCH3 / 0.5 h / 40 °C
View Scheme
参考文献
Tisdale, Eric J.; Kochman, David A.; Theodorakis, Emmanuel A.
Tetrahedron Letters, 2003 , vol. 44, # 16 p. 3281 - 3284
