反式-1-苯甲酰基-4-羟基-L-脯氨酸甲酯合成路线 （共 8 条）
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water 1.5 h; Ambient temperature;
参考文献
Baldwin, Jack E.; Bamford, Samantha J.; Fryer, Andrew M.; Rudolph, Martin P. W.; Wood, Mark E.
Tetrahedron, 1997 , vol. 53, # 14 p. 5233 - 5254
反应条件
sodium carbonate T=0°C; 4 h;
参考文献
Yoshifuji; Kaname
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 8 p. 1302 - 1306
反应条件
1.1: SOCl2 / 0.5 h / -10 °C 1.2: 20 °C 2.1: 47.0 g / aq. NaHCO3 / dioxane / 4 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 51, # 8 p. 1015 - 1020
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine T=20°C; 144 h;
参考文献
Arakawa, Yasushi; Ohnishi, Masafumi; Yoshimura, Norikazu; Yoshifuji, Shigeyuki
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 8 p. 1015 - 1020
反应条件
1: 1. Et2NSF3, Pyridine 2. LiOH / 1. CH2Cl2 2: 70 percent Chromat. / AlCl3 / benzene / Ambient temperature View Scheme
参考文献
Kronenthal; Mueller; Kuester; Kissick; Johnson
Tetrahedron Letters, 1990 , vol. 31, # 9 p. 1241 - 1244
反应条件
1: 77 percent / pyridine 2: 96 percent / NaN3 / dimethylformamide / 60 °C 3: 87 percent / aq. LiOH / tetrahydrofuran 4: 100 percent / H2 / Pd-C / methanol View Scheme
参考文献
Curran, Timothy P.; Chandler, Nicole M.; Kennedy, Robert J.; Keaney, Meghan T.
Tetrahedron Letters, 1996 , vol. 37, # 12 p. 1933 - 1936
反应条件
1: 91 percent / pyridine; 4-dimethylaminopyridine / 144 h / 20 °C
2: 97 percent / NaBH4 / tetrahydrofuran; methanol / 2 h / Heating
3: 70 percent / aq. H2O2; pyridine / CH2Cl2 / 2 h / 20 °C
4: H2 / PtO2 / methanol / 12 h / 1520 Torr
View Scheme
参考文献
Arakawa, Yasushi; Ohnishi, Masafumi; Yoshimura, Norikazu; Yoshifuji, Shigeyuki
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 8 p. 1015 - 1020
反应条件
triethylamine in toluene
T=60 - 70°C; Product distribution;
参考文献
Anderson, Neal G.; Lust, David A.; Colapret, Kay A.; Simpson, James H.; Malley, Mary F.; Gougoutas, Jack Z.
Journal of Organic Chemistry, 1996 , vol. 61, # 22 p. 7955 - 7958
