N-苯甲酰基-反式-4-对甲苯磺酰氧基-L-脯氨酸甲酯合成路线 （共 4 条）
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine T=20°C; 144 h;
参考文献
Arakawa, Yasushi; Ohnishi, Masafumi; Yoshimura, Norikazu; Yoshifuji, Shigeyuki
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 8 p. 1015 - 1020
反应条件
1: 47.0 g / aq. NaHCO3 / dioxane / 4 h / 20 °C 2: 91 percent / pyridine; 4-dimethylaminopyridine / 144 h / 20 °C View Scheme
参考文献
Arakawa, Yasushi; Ohnishi, Masafumi; Yoshimura, Norikazu; Yoshifuji, Shigeyuki
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 8 p. 1015 - 1020
反应条件
1.1: SOCl2 / 0.5 h / -10 °C 1.2: 20 °C 2.1: 47.0 g / aq. NaHCO3 / dioxane / 4 h / 20 °C 3.1: 91 percent / pyridine; 4-dimethylaminopyridine / 144 h / 20 °C View Scheme
参考文献
Arakawa, Yasushi; Ohnishi, Masafumi; Yoshimura, Norikazu; Yoshifuji, Shigeyuki
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 8 p. 1015 - 1020
反应条件
1: 97 percent / NaBH4 / tetrahydrofuran; methanol / 2 h / Heating
2: 70 percent / aq. H2O2; pyridine / CH2Cl2 / 2 h / 20 °C
3: H2 / PtO2 / methanol / 12 h / 1520 Torr
View Scheme
参考文献
Arakawa, Yasushi; Ohnishi, Masafumi; Yoshimura, Norikazu; Yoshifuji, Shigeyuki
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 8 p. 1015 - 1020
